There is a very limited number of studies investigating cognition in models of CNS disease with Nrf2-deficient mice, with only one study [40] reporting an exacerbated spatial learning and memory deficits and working and associative memory deficits in an Nrf2-deficient APP/PS1 mutant model of Alzheimer’s disease. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.