Taken together, our data show that resident CD45intTmem119+P2RY12+ cells are capable of upregulating their CD45 while downregulating Tmem119 and P2RY12 expression in neuroinflammatory conditions such as stroke, CAA, or aging and may reside within the CD45highCD11b+ gate, conventionally designated as “infiltrating myeloid cells.” Importantly, the CD45high subpopulation of MG within the CD45highCD11b+ gate, albeit small, may be functionally more important in maintaining immune vigilance in the brain, as suggested by higher MHC-II expression levels [42, 43]. The gene discussed is TMEM119; the disease is Stroke.