Consistent with recent studies in pre-clinical models of Alzheimer’s disease (AD) and EAE [48, 50–52], we also report both Tmem119 and P2RY12 expression are decreased after acute ischemic stroke, after the development of symptoms in CAA models, and in ex vivo models of inflammation for sorted MG. The gene discussed is P2RY12; the disease is early-onset autosomal dominant Alzheimer disease.