Age (per year) (AOR 1.05, p = 0.027), low sTWEAK (< 7.2 ng/ml) (AOR 9.0, p = 0.006), high galectin-3 (AOR 6.3, p = 0.001), HDL-cholesterol (per mmol/l) (inversely) (AOR 0.1, p = 0.006), and use of antidepressants (AOR 8.4, p < 0.001), were associated with depression. This evidence concerns the gene LGALS3 and major depressive disorder.