After adjustment for age, gender, UACR, diabetes and CRP, body mass index, waist-hip ratio (WHR), alcohol consumption, cholesterol and triglycerides, only low concentrations of serum albumin (p < 0.001) and haemoglobin (p = 0.012), and high concentrations of bilirubin (p = 0.011) were significantly associated with annual decline in eGFR. This evidence concerns the gene CRP and diabetes mellitus.