Clinical verification using individual blood plasma from 52 GBC cases (GBC stage I, II, III and IV) and 89 controls (healthy volunteers and GSD cases) (Table 1) showed significantly high autoantibody levels for ANXA1 in early stage GBC (stage I and II) as well as in GBC Stage IIIA (p value < 0.05) (Fig. 3a, Table 2). This evidence concerns the gene ANXA1 and disorder of glycogen metabolism.