In a MCF-7/ADR tumor xenograft model, CA4/Pasp-DOX/PEG-Phis showed superior in vivo anticancer efficacy to the controls (free DOX, free CA4, free DOX and CA4 combination, Pasp-DOX, Pasp-DOX + CA4, and CA4/DOX/PEG-Phis). Here, CA4 is linked to neoplasm.