In addition, quantitative analysis of PGE2, COX-2, and anti-apoptotic BCL-2 proteins that induce resistance to chemotherapy in mice tumor tissues showed that MSN-CXB/PTX effectively inhibited the COX-2/PGE2 pathway and the expression of BCL-2 proteins, thus having superior tumor cell death compared to control groups [166]. This evidence concerns the gene PTGS2 and neoplasm.