In an in vivo anticancer effect study in nude mice bearing HT-1080 tumor, it was confirmed through tumor size and survival rate that MSN-CXB/PTX showed a better therapeutic effect than the control groups (PBS, MMP-2-insenitive nanospheres loaded with single drug (MIN-PTX, MIN-CXB, and MIN loaded with CXB/PTX (MIN-CXB/PTX)). This evidence concerns the gene MMP2 and neoplasm.