We further conclude that the here applied infection model of LOS-sensitized secondary abiotic IL-10−/− mice, which had initially been established to unravel C. jejuni-host interactions, mimicking severe human campylobacteriosis, can also be used to study the molecular mechanism underlying C. coli-induced immunopathogenesis and, hence, paves the way to develop therapeutic and prophylactic options to combat campylobacteriosis as well as post-infectious sequelae. Here, IL10 is linked to infection.