In the gene set enrichment (GSE) data set analyzed, previously published elsewhere [15], the volcano plot shows an enrichment of the expression of genes related to activation of HSCs and accumulation of extracellular matrix proteins, such as Col1a1 (collagen, type I, alpha1) and Col1a2 (collagen, type I, alpha2), genes involved in transforming growth factor (TGFβ) signaling, such as CD63, and biomarkers of Kuppffer cells, such as the glycoprotein nonometastatic melanoma B (Gpnmb). The gene discussed is CD63; the disease is melanoma.