Moreover, combined MCL and cHL lymphoma is also described and a divergent clonal evolution from a common precursor has been hypothesized [43,44], leading to RSLC in MCL and/or RSC in cHL combined with MCL because of EBV infection, acquisition of additional genetic aberrations such as PD-L1/2 amplification, and certain mutations such as TP53 [44,45] (Supplementary Table S2). This evidence concerns the gene TP53 and classic Hodgkin lymphoma.