By definition, both tumors strongly express CD30, but the expression of PAX5, in addition to CD15 and EBV−LMP1/EBER expression, strongly supports a diagnosis of cHL, while expression of T cell-associated markers or cytotoxic markers supports a diagnosis of ALCL; finally, the staining for ALK protein is decisive for the diagnosis of ALK+ ALCL [9,12]. The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.