Immunohistochemical studies showed that an increased expression of the NLRP3 inflammasome constituents, of (pro)caspase-1, and of the inflammasome activation products IL-1β and IL-18 colocalized with glia maturation factor (GMF), APOEε4, autophagic SQSTM1/p62- and LC3-positive vesicles, and the lysosomal marker LAMP1 in tissue samples from the temporal cerebral cortex of AD brains. Here, NLRP3 is linked to Alzheimer disease.