The NLRP3 inflammasome (aka NLRP3-ASC or NOD-like receptor protein 3 [NACHT, LRR, and PYD domains-containing protein 3]), is involved in inflammatory and degenerative diseases typical of ageing that is in ailments characterized by the intra-tissue hoarding of peptides or crystals such as AD (Aβs), atherosclerosis (cholesterol), and gout (monosodium urate); in fibrotic diseases; and in metabolically stressful conditions, such as nonalcoholic hepatic steatosis, and type-2 diabetes [238]. This evidence concerns the gene NLRP3 and neurodegenerative disease.