Moreover, in brain/cerebral endothelial cells (BECs/CECs) RAGE neutralization via a specific antibody effectively blocked the Aβ-induced activation of ERK and JNK signaling that otherwise led to an increased matrix metalloproteinase-2 (MMP-2) expression exacerbating vascular inflammatory stress in both cerebral amyloid angiopathy (CAA) and AD [151]. The gene discussed is MMP2; the disease is Alzheimer disease.