Importantly, CaSR NAM NPS 2143 totally suppressed the Aβ•CaSR-elicited oversecretion of IL-6 and partially yet significantly that of ICAM-1, RANTES, and MCP-2, proving that human astrocytes Aβ•CaSR signaling could directly advance AD’s neuroinflammation [13]; (viii) the slow yet progressive death of the human cortical neurons, which was fully prevented by CaSR NAM NPS 2143; conversely, the NAHAs survived and kept producing and releasing all the above-mentioned detrimental factors [33]. Here, CASR is linked to Alzheimer disease.