The evidences gained from the experimental use of preclinical in-vitro (”in a Petri dish”) AD-models made of nontumorigenic human neurons and astrocytes indicate that the first AD drivers are the soluble or fibrillar Aβs, which, however, act alone for a very short time, as they directly induce the production and release of additional amounts of Aβs and concurrently of the other two main AD drivers, i.e., p-Taues and neuroinflammation [13,33,299,302]. Here, DDX41 is linked to Alzheimer disease.