PYCARD and Alzheimer disease: Saadi et al. [230] used streptozotocin (STZ) injected male Wistar rats as experimental AD-like models and determined the expression of genes implicated in the inflammasome complex, such as NLRP1, NLRP3, NLRC4, AIM2, ASC or PYCARD, IL-1β, IL-18, and CASPASE-1.