MAPT and Alzheimer disease: But other nearly undetectable factors asymptomatically (for most of the time) yet relentlessly drive AD’s progression, such as soluble Aβ oligomers (sAβ-os) [5]; soluble p-Tau oligomers (p-Tau-os) [6]; reactive oxygen species (ROS) [7,8]; nitric oxide (NO) and its peroxynitrite derivative (ONOO−) [9]; vascular endothelial growth factor-A (VEGF-A) [10]; and a set of proinflammatory cytokines, chemokines, and other toxic agents [11,12,13].