Consequently, TREM2 knockout microglia does not enfold and compact Aβ plaques and does not form an isolating barrier preventing the plaques branching diffusion, the Aβ subspecies plaque content alteration, and the Aβ-related damage to dystrophic axons and dendrites, synaptic connections, and neurons in AD’s early stages [95,99]. This evidence concerns the gene TREM2 and Alzheimer disease.