DDX41 and Alzheimer disease: Concerning AD, SR-As of astrocytes and microglia (i) bind fAβs and sAβ-os; (ii) induce Aβs phagocytosis; and (iii) activate intracellular MAPK signaling cascades, thus helping curtail the brain Aβs load and decreasing the release of proinflammatory cytokines [158,159].