CASR and Alzheimer disease: Interestingly, Feng et al. [335] reported that CaSR NAM NPS 2143 prevented the loss of neuronal dendritic filopodia and synaptic spines, the downregulation of the presynaptic marker synaptotagmine-1, and of the postsynaptic marker PDS 95, and mitigated cognitive deficits induced by Aβ1-42-os in B6C3-Tg (APPswe/PSEN1dE9) AD-model mice and in cultured primary hippocampal neurons.