The reasons for this discrepancies are still unclear; however, it is possible that adiponectin production responds to adaptation mechanisms (especially in overweight children or those with mild obesity) as observed in Murdolo et al.’s [50] study, where the total adiponectin levels of children with obesity were not different from the normal-weight group and were even higher in overweight boys. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.