Excessive accumulation of adipose tissue and increased secretion of proinflammatory mediators including acute phase proteins (e.g., C Reactive Protein [CRP]), cytokines (e.g., Interleukin 6 [IL-6]) and some adipokines create a state of chronic, low-grade systemic inflammation that provides a substrate for disease-related processes such as insulin resistance, which is associated with metabolic syndrome and type 2 diabetes mellitus [5,6]. The gene discussed is CRP; the disease is Insulin resistance.