CD4 and neoplasm: Interestingly, matched TME and NAT (n = 8) did not exhibit significant differences (Figure 7A), while matched TME–tumour pairs (n = 18) indicated an expected enrichment of CD27, CD3, CD4, CD44, CD45, CD45RO, CD68, CD163, and VISTA within the TME, while tumour regions were enriched in Ki-67, EpCAM, and cytokeratin (Figure 7B).