Interestingly, it was previously reported that high gene expression of COL6A3 in stroma is linked to poor OS in CRC [147], while high expression of the HKDC1 gene is related to poor OS in hepatocarcinoma [148], indicating that the biomarker value of some AS events is tumor-type or -stage specific. The gene discussed is COL6A3; the disease is colorectal carcinoma.