MMP2 and neoplasm: Our data showed the significant bioactivity of CA and GA in the inhibition of tumor cell proliferation, tumor growth, and angiogenesis, indicating that CA and GA play a critical role in the inhibition of VEGF, MMP-2, and MMP-9 (Figure 4 and Figure 5); macrophage polarization (Table 3); cell migration; and the inhibition of ROS (Figure 6, Table 4); our findings are in accordance with the data of other authors [29].