Thus, through multiple mechanisms, including antitumor, antioxidant, anti-inflammatory, and immunomodulatory effects, GA or CA alter the tumor microenvironment, leading to a reduction in the VEGF levels and metalloproteinase activity; this results in a reduction in vascular density and permeability, and a reduction in the level of ascites fluid accumulation that is a crucial nutritional factor for the growth and survival of tumor cells. Here, VEGFA is linked to neoplasm.