The potential of CK1δ/ε-specific and CK1α-specific inhibitors in leukemia, lymphoma and myeloma therapy is better described, and will be discussed below, including the rationale for targeting CK1δ/ε in B cell lymphomas and CK1α in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Here, CSNK1A1 is linked to plasma cell myeloma.