MCL is a specific type of non-Hodgkin B cell lymphoma bearing the recurrent t(11;14)(q13;q32) chromosome translocation which brings the cyclin D1 gene under the influence of the enhancer of the immunoglobulin heavy chain (IgH) gene, leading to cyclin D1 overexpression [68]. The gene discussed is CCND1; the disease is B-cell non-Hodgkin lymphoma.