CXCL12 and B-cell chronic lymphocytic leukemia: Overall, high expression of non-canonical Wnt pathway genes and proteins was shown to correspond with poor outcome of CLL patients [28,62,88], deregulated motility (specifically for CLL cells with high autocrine expression of the Wnt5a ligand) and chemotaxis towards CXCL12 and CCL19 chemokines [28,30,89].