The non-canonical Wnt signaling pathway, which is dependent on CK1, is known to mediate inflammatory response and WNT-5A has been implicated in many inflammatory conditions such as rheumatoid arthritis [136], osteoarthritis [137] and psoriasis vulgaris [138] or recently has been described as a reliable biomarker for monitoring of pathological progression in SARS-CoV-2 patients [139]. This evidence concerns the gene CSNK1A1 and rheumatoid arthritis.