In addition, CK1 inhibition can modulate T cells—CK1δ was shown to be essential for the formation of the immunological synapse [140] and CK1ε inhibition by umbralisib and PF-4800567 could protect Tregs and prevent immune system mediated toxicities in CLL patients treated with PI3K inhibitors [96,133]. The gene discussed is CSNK1A1; the disease is B-cell chronic lymphocytic leukemia.