Generally, cytokines play a central role in the pathogenesis of allergic inflammation [44], with related studies documenting that both pro-inflammatory cytokines and chemokines, including TNF-α, IL-6, NO, and CXCL8, contribute to the pathogenesis and exacerbation of allergic asthma [45]. The gene discussed is CXCL8; the disease is allergic asthma.