In the K7M2 osteosarcoma model, IL-18 seems to be implicated in MDSC recruitment at the tumor site and the association of anti-PD-1 with IL-18BP (an inhibitor of IL-18) increases the proportion of CD8+ IFNγ+ GzmB+ T cell tumor infiltration, and decreases tumor weight [81]. This evidence concerns the gene IFNG and neoplasm.