CD8A and melanoma: On the other hand, stimulation of BRAFV600E PTEN−/− melanoma cells (but also Lewis lung carcinoma cells) with antigen-specific CD8+ T cells (or with IFNγ, the cytokine produced by these cells) in the presence of anti-PD-L1 antibody, drives NLRP3 inflammasome and caspase-1 activation.