LCA2 is characterized by very early-onset night blindness due to the loss of rod photoreceptor function and structure with a concomitant retention of some cones, particularly in the central foveal region, which can provide ambulatory daytime vision into the third decade well after all peripheral vision has deteriorated in some individuals; however, legal blindness by late teens is also a common feature within this patient group [21,22,23]. This evidence concerns the gene RPE65 and night blindness.