Furthermore, it is notable, as evidenced by a comparison of the various knock-in models, that even within the inbred C57Bl6/J mouse strain, the D477G RPE65 variant can give rise to (subtly) different phenotypes in a manner similar in nature (but not in magnitude) to the clinical spectrum observed in patients, which ranges from asymptomatic through “classical RP” to severe macular atrophy and choroidal degeneration [32,33,34,35,39] and Section 4, above. Here, RPE65 is linked to retinitis pigmentosa 1.