A previous study of lung cancer cell lines reported that miR-21-5p could modulate the effect of EZH2 on the biological behavior of human lung cancer stem cells [32], suggesting that the association of exosomal miR-21-5p with poor prognosis in ENKTL might be due to its effect on EZH2. The relation of exosomal miR21-5p to EZH2 expression in ENKTL needs to be evaluated in future studies. Here, EZH2 is linked to lung carcinoma.