The polyGP is more abundant in cells and neuronal tissues of SCA36 than in C9ORF72 FTD/ALS subjects, however, contrarily to polyGP insoluble cytoplasmic aggregates found in C9ORF72 FTD/ALS, they remain soluble in the cytoplasm of neuronal cells in SCA36 [13,14]. The gene discussed is NOP56; the disease is amyotrophic lateral sclerosis.