PIK3CD and autoimmune hemolytic anemia: Moreover, mutations in genes implicated in primary immunodeficiencies (TNFRSF6, CTLA4, STAT3, PIK3CD, CBL, ADAR1, LRBA, RAG1, and KRAS) have been reported in about 40% of pediatric Evans syndrome (the association of AIHA and primary thrombocytopenia) [28].