However, crucial EMT-activating transcription factors, including Snails, ZEB, and Twist, recognize the E-box DNA sequences in the promoter region of the ABCC4 gene, and the bioinformatic analysis of the ABCC4 promoter region revealed the presence of 11 E-box sequences [12]; thus, we assume that the ABCC4 upregulation is correlated with the epithelial reprogramming process rather than with the activity of a single transcription factor during epithelial transition in CRC. The gene discussed is ZEB1; the disease is colorectal carcinoma.