cAIHA patients would often experience disabling symptoms due to the agglutination of erythrocytes at lower temperatures that occurs in the peripheral circulatory districts of fingers, nose, ears, etc. IgM autoantibodies also fix complement and may induce intravascular hemolysis, although extravascular hemolysis in the liver remains the main pathogenic mechanism [3,13]. This evidence concerns the gene CD40LG and autoimmune hemolytic anemia, cold type.