Each marker has possible confounders that should be excluded basing on clinical evaluation and laboratory tests (i.e., B12 deficiency for high LDH, liver failure and congenital hypo-haptoglobinemia for low haptoglobin, Gilbert syndromes for increased unconjugated bilirubin, and bleeding for reticulocytosis) [9]. The gene discussed is HP; the disease is Hepatic failure.