Depletion of IRAK4 showed a negative effect on NF-κB activity and autocrine IL-6/IL-10 engagement of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription 3 (STAT3) pathway, reducing survival of DLBCL cells [42,43]. This evidence concerns the gene IL6 and diffuse large B-cell lymphoma.