Calycosin (27), an isoflavonoid from the Chinese medicinal herb Astragalus propinquus, induces Nrf2 that suppresses the expression of proinflammatory cytokines via p62/Nrf2-linked HO-1 induction in rheumatoid arthritis synovial fibroblasts [153]. Here, NFE2L2 is linked to rheumatoid arthritis.