HMOX1 and Sepsis: Jeong et al. suggested the α-methylene-γ-butyrolactone moiety in dehydrocostus lactone (70) is crucial for cytoprotective HO-1 expression through activation of the Nrf2 [233], and Park et al. suggested that dehydrocostus lactone (70) might be useful for the treatment of sepsis through the mechanism [234].