MAPT and Alzheimer disease: The neuropathologic changes in AD include accumulation of Aβ in the cerebral cortex in the form of plaques and in the blood vessel walls as cerebral amyloid angiopathy (CAA); phosphorylated tau in the form of tangles, neuropil threads, and plaque-associated dystrophic neurites; the activation of microglia and astrocytes; neuronal and synaptic dysfunction and loss, and cerebral atrophy [8].