In a comprehensive transcriptome analysis of hypoxic NK cells, Parodi et al. observed the downregulation of IFN-γ and several members of the TNF family, including TNF-α, LTA, LTB, TNFSF14, TNFSF10, and TNFSF11, which are involved in triggering tumor immunogenicity and decreasing tumor proliferation [177]. The gene discussed is IFNG; the disease is neoplasm.