The SNVs in FAM136A, DTNA, PRKCB, COCH, DPT and SEMA3D have and AD inheritance pattern; specifically, there are variants in PRKCB, COCH, DPT and SEMA3D segregates with an incomplete penetrance because in the families reported, there were some relatives that presented an incomplete phenotype of MD. Here, SEMA3D is linked to Alzheimer disease.