A more recent study that compares inositols to other treatment strategies (COC and metformin) shows that inositol therapies (either MI + folic acid or MI + DCI + folic acid) improved significantly insulin resistance and glycosylated hemoglobin, reducing cholesterol and triglyceride levels and blood pressure (when used for more than 3 months), while COC treatment worsened insulin resistance and lipid parameters (increasing cholesterol and triglyceride levels), reducing significantly at the same time FSH, LH, and SHBG serum levels [85]. The gene discussed is PLOD1; the disease is Insulin resistance.