TERT and breast cancer: In addition, we observed a high concordance of mutational status between tumors and matched urine samples in DIAGURO BC cases with analytical sensitivities of 98.6% for UroMuTERT and 97.2% for ddPCR assays and therefore only a small fraction of false negatives, likely reflecting in such cases the existence of minor tumoral TERT mutated clones (MAF < 1%) undetectable in urine samples.