We specifically showed in case-control studies that urinary TERT promoter mutations have excellent sensitivity and specificity for the detection of BC [11] and that these mutations could also be detected in urinary DNA of asymptomatic individuals years prior to primary diagnosis of BC with high specificity [12], highlighting their potential to be used as simple and inexpensive non-invasive biomarkers for early detection of BC. Here, TERT is linked to breast cancer.