NFKB1 and neoplasm: Related to the possible reasons involving caloric restriction, the GSPE tumor suppressing effect may be explained by its modulation of antiproliferative and proapoptotic genes [53] such as the tumor suppressing factor p53 [54] and NF-κβ [55] observed in different cancerous cell lines, their anti-inflammatory properties [56] and antioxidant properties [57].