Quercetin protected against doxorubicin-induced cardiomyopathy in rats by increasing the levels of antioxidant defense molecules such as the nuclear factor erythroid 2-related factor 2 (Nrf2), which is a regulator of cellular defense against oxidative stress as well as via the restoration of histological and biochemical defects [19]. This evidence concerns the gene NFE2L2 and cardiomyopathy.