However, here we detect distinct myocardial transcriptomic profiles in patients affected with different genetic cardiomyopathies in refractory heart failure (stage D) stratified by the affected genes (LMNA, PKP2, RBM20 and TTN) and not based on the clinical phenotype (DCM or ARVC). This evidence concerns the gene RBM20 and familial dilated cardiomyopathy.