LMNA and cardiomyopathy: There are significant molecular differences in the myocardial transcriptomes based on the mutant gene, even though the clinical phenotype (type of cardiomyopathy) seems identical: For example, DCM patients with mutations in LMNA show unique, significantly differentially regulated genes, pathways and GO terms which were not identified in the myocardial transcriptome of samples with mutations in RBM20, even though clinically, both sample types are derived from patients with DCM.