PKP2 and Ventricular arrhythmia: The myocardium of patients with mutations in LMNA is widely associated with upregulated genes and pathways involved in immune response, like cytokine production, whereas mutations in PKP2 lead to a downregulation of genes of the ECM, which might diminish force generation and lead to lower affinity of desmosomal cadherins resulting in ventricular arrhythmia.