The myocardium of patients with mutations in LMNA is widely associated with upregulated genes and pathways involved in immune response, like cytokine production, whereas mutations in PKP2 lead to a downregulation of genes of the ECM, which might diminish force generation and lead to lower affinity of desmosomal cadherins resulting in ventricular arrhythmia. This evidence concerns the gene LMNA and Ventricular arrhythmia.