The AORs of PAI-1 −675 4G5G + 5G5G group when combined with each parameters including hypertension, DM, hyperlipidemia, ≥25 kg/m2 of BMI, ≥150 mg/dL of triglyceride levels, and <40 (male)/<50 (female) mg/dL of HDL-cholesterol levels are 2.780 (p < 0.0001), 3.266 (p < 0.0001), 1.779 (p = 0.011), 4.050 (p < 0.0001), 1.714 (p = 0.011), and 6.781 (p < 0.0001). The gene discussed is SERPINE1; the disease is hyperlipidemia.