SERPINE1 and coronary artery disorder: In contrast, AA/4G5G (AOR, 13.157; p = 0.022) of PAI-1 −844 G > A/PAI-1 −675 4G > 5G, GG/GA (AOR, 2.215; p = 0.010) of PAI-1 −844 G > A/PAI-1 +43 G > A, 4G5G/GA (AOR, 2.089; p = 0.017) and 5G5G/GA (AOR, 2.558; p = 0.010) of PAI-1 −675 4G > 5G/PAI-1 +43 G > A genotype combinations are associated with a highly increased CAD risk.