In haplotype analysis of the PAI-1 −844 G > A/PAI-1 −675 4G > 5G/PAI-1 +43 G > A polymorphisms, G-4G-A (OR, 0.118; p < 0.0001), A-4G-A (OR, 0.019; p < 0.0001), G-5G-A (OR, 1.989; p = 0.005), and A-5G-A (OR, 4.728; p = 0.002) are associated with CAD susceptibility. Here, SERPINE1 is linked to coronary artery disorder.