SERPINE1 and coronary artery disorder: In the PAI-1 −675 4G > 5G/PAI-1 +43 G > A genotype combination analysis, the PAI-1 −675 4G5G/PAI-1 +43 G > A combination shows that the susceptibility of CAD was gradually increased when the genotype of PAI-1 +43 G > A was GA and the genotypes of PAI-1 −675 4G > 5G changed from 4G4G to 5G5G.