Sox17 can inhibit human HCC cell growth by negatively regulating the canonical Wnt/β-catenin signaling pathway [146], while as a tumor suppressor, GABARAPL1 inhibits Wnt signaling by the mediation of Dvl2 degradation suggested that the inhibition role of GABARAPL1 on the Wnt signaling is autophagy dependent [147]. Here, DVL2 is linked to neoplasm.