APP and Dravet syndrome: Despite the high incidence of CHDs in DS, the pathophysiology and the pathways behind them remain unknown, as well as the close relationship with DS.Gene mapping analysis studies on human chromosome 21 (HSA21) have revealed that the supernumerary genes related to DS onset (such as superoxide dismutase Cu/Zn, transcription factors, stress inducible factors, cytokine receptors and amyloid precursor protein) that codify molecules witha key role in different metabolic pathways involved in diverse processes, such as angiogenesis, as well as maintaining cardiovascular homeostasis [9].