In this view, our results allow us to hypothesize that minor genetic variants of the interferon receptor gene cluster (i.e., IFNGR2 rs2834213 G homozygous genotype and IL10RB rs2834167 G positive genotypes) on HSA21 might be considered as tags ofa complex genetic constellation involving over-dosage of genetic susceptibility variantsonHSA21 and the presence of other susceptibility alleles on other chromosomes, resultingin CHDsfrequently, but not exclusively, associatedwith DS. The gene discussed is IFNGR2; the disease is Dravet syndrome.