Based on these observations, we analyzed the frequencies of IFNAR2 rs2229207, IFNGR2 rs2834213, IL10RB rs2834167 and VEGFA rs3025039 SNPs in a group of young adults withDS compared to a group of healthy subjects, matched for age and gender, in order to evaluate whether these polymorphisms can influence the susceptibility of patients with DS to either CHDs or acquired defects. This evidence concerns the gene VEGFA and Dravet syndrome.