VEGFA and Dravet syndrome: A study, conducted on strains of mice that were trisomic for segments of MMU16, homologous to HSA21, demonstratedan overexpression of vascular endothelial growth factor (VEGF) in severe DS heart abnormalities, including an attenuated compact layer of myocardium, the overproduction of trabeculae, defective ventricular septation and remodeling of the outflow tract [20].