ABC subtype lymphomas frequently harbor mutations in the B-cell receptor (BCR) and the NF-kB pathway genes (MYD88, CD79A/B, CARD11, TNFAIP3), and display chronic active BCR signaling, whereas those of the GCB subtype commonly display BCL2 and/or MYC gene rearrangements, as well as genetic lesions in EZH2 and PTEN [17,18]. The gene discussed is BCL2; the disease is lymphoma.