The development of EZH2 inhibitor tazemetostat as monotherapy or in combination with prednisolone has been stalled (NCT01897571), but is under study in combination with atezolizumab in R/R DLBCL (NCT02220842), and R-CHOP as a first-line treatment for newly diagnosed DLBCL patients (NCT02889523). This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.