Furthermore, R/R DLBCL-enriched inactivating gene lesions target NFKBIE [34,51], which will lead to NF-kB-mediated production of IL-6 and IL-10 resulting in autocrine signaling and constitutive activation of JAK1/2 and STAT3 [115,116]. Here, STAT3 is linked to diffuse large B-cell lymphoma.