IFNA1 and cancer: A recombinant lentogenic NDV strain (Hitchner B1) expressing the influenza A virus IFN antagonist protein NS1, which suppresses RIG-1 receptor signaling, IRF3 dimerization, and expression of IFN-β, potently reduced IFN signaling across a panel of cancer cell lines and resulted in increased NDV replication and cytolysis [50].