Furthermore, immunohistochemistry (IHC) staining of 12 liver cancer tissues obtained from the ISU ABXIS cohort showed that Cdh1 was predominantly expressed in the cytoplasm of hepatocarcinoma cells and normal hepatocytes; and the expression level of Cdh1 was significantly upregulated in HCC tissues than in the non-neoplastic tissues (Figure 7D, upper panel, Figure S1B). This evidence concerns the gene CDH1 and hepatocellular carcinoma.