IL-1β is a potent pro-inflammatory cytokine that is crucial for host-defense responses to infection and injury [54,55]; it is involved in chronic inflammation such as rheumatoid arthritis, neuropathic pain, inflammatory bowel disease, osteoarthritis, vascular disease, multiple sclerosis, and Alzheimer’s disease [56]. The gene discussed is IL1B; the disease is early-onset autosomal dominant Alzheimer disease.