Hypersialylation further facilitates several aspects of tumorigenesis including (1) immune evasion through immune inhibitory Siglecs (Immune inhibitory receptors), (2) enhancement of tumor proliferation and metastasis through cytoskeleton-related protein, (3) promotion of tumor angiogenesis through the interaction between VEGF and polysialic acid, and (4) resistance to apoptosis through anti-apoptosis/kinase inhibitors [14]. The gene discussed is VEGFA; the disease is neoplasm.