To evaluate the extent of WNT ligand modulation in BC cell models, Benhaj et al. reported that most BC cell lines overexpressed members of the WNT ligand family, such as WNT3A, WNT4, WNT6, WNT8B, WNT9A and WNT10B, whereas the expression of WNT5A, WNT5B and WNT16 was usually downregulated. Here, WNT16 is linked to breast cancer.