In this context, BC gene expression profiling of 114 basal-like BC samples significantly associated SOX9, a member of the SOX family of transcription factors and an important mediator of the (epithelial–mesenchymaltransition (EMT) cell program, with the expression of LRP6 and transcription factor 4 (TCF4), two major components of the canonical Wnt/β-catenin pathway. The gene discussed is LRP6; the disease is breast cancer.