CCNB1 and Familial prostate cancer: Consistent with these previous research studies, cyanidin 3-glucoside and peonidin 3-glucoside resulted in G2/M phase arrest due to the downregulation of cyclin B1 and CDK1 [53,54], and lipophilic GSP, resveratrol and silybin induced cell cycle arrest by enhancing the expression of p21 in prostate cancer cells [35,55,56], we also found that GSPs treatment induced the downregulation of cyclin B1 and CDK1 and upregulation of p21 of HepG2 cells (Figure 4C).