Consistent with these previous research studies, cyanidin 3-glucoside and peonidin 3-glucoside resulted in G2/M phase arrest due to the downregulation of cyclin B1 and CDK1 [53,54], and lipophilic GSP, resveratrol and silybin induced cell cycle arrest by enhancing the expression of p21 in prostate cancer cells [35,55,56], we also found that GSPs treatment induced the downregulation of cyclin B1 and CDK1 and upregulation of p21 of HepG2 cells (Figure 4C). This evidence concerns the gene CCNB1 and prostate cancer.