To test whether TYK2 expression was altered in B-ALL patients, we performed RT-qPCR in bone marrow samples of 88 B-ALL patients at diagnosis (67 paediatric, age ranging from 1 to 17 years, median 5, mean 6.9; 21 adults, ranging from 21 to 90, median 48, mean 49.9) compared to PBMCs of 105 healthy donors (seven umbilical cords and 98 adults with age ranging from 19 to 66 years (median 33, mean 35.1)) (Figure 6). This evidence concerns the gene TYK2 and acute lymphoblastic leukemia.