RA patients showed the up-regulation of several genes such as TLR5, TLR2, and SIGIRR/IL1R8 compared with SLE and TLR5, TLR3, IL1RAP/IL1R3, SIGIRR/IL1R8 and IL18R1 in relation to SSC. This evidence concerns the gene TLR3 and rheumatoid arthritis.