In line with this, Helen L. et al. also showed that the expression of a signature of three genes from neutrophils of RA patients including CMPK2, IFIT1B and RNASE3 at baseline was predictor of anti-TNFα response following EULAR criteria at 12 weeks with an area under the curve of 0.94 [117]. This evidence concerns the gene TNF and rheumatoid arthritis.