The IPA functional analysis of the predicted targets of this miRNA signature suggested that they were involved in pathways directly associated with the disease such as the role of IL-17A in RA, the role of osteoblasts, osteoclasts and chondrocytes in RA, the role of macrophages, fibroblasts and endothelial cells in RA, and STAT-3 or IL-6 signaling. The gene discussed is STAT3; the disease is rheumatoid arthritis.