The myotubularin cDNA, together with the regulatory elements, can be packaged in an AAV, and two very good murine and canine models of the disease recapitulate the main features of the pathology, noticeably, histological defects specific to centronuclear myopathies, generalised muscle hypotrophy and weakness, and lifespan reduction [239,240,241]. This evidence concerns the gene MTM1 and centronuclear myopathy.