In a study by Morishita et al., loading of murine melanoma B16-BL6 cell-derived EVs by TAA and streptavidin-lactadherin enhanced the delivery of biotinylated CpG DNA and immunization of B16-BL6 tumor-bearing mice with these engineered EVs resulted in strong antitumor effects [93]. Here, MFGE8 is linked to neoplasm.