TGFB1 and breast carcinoma: EVs derived from human multiple myeloma cells, renal cells, and murine breast carcinomas triggered the differentiation and proliferation pathways in MDSCs, which depends on the activation of STAT3 signaling and also the presence of prostaglandin E2 PGE2, Hsp72, and TGF-β in the TD-EVs cargo [7,49,50].