LMNA and Hutchinson-Gilford progeria syndrome: For example, Hutchinson-Gilford progeria syndrome (HGPS) is caused by a splicing error that affects the LMNA gene; this results in organ-specific aging-like symptoms such as alopecia, atherosclerosis, increased joint immobility, osteolysis, severe lipodystrophy, scleroderma and various degrees of skin hyperpigmentation [3,4,5,6].