THOP1 and early-onset autosomal dominant Alzheimer disease: One canonical pathway, “Neuroprotective Role of THOP1 in Alzheimer’s Disease”, was marginally significantly enriched in humans (−log (p-value) = 1.35; p = 0.045) but not in mice (−log (p-value) = 0.796; p = 0.160) (Figure 4).