PON1 and Venous thrombosis: As genetic variants of SERPINC1 are known to be associated with venous thrombosis in humans [32], the downregulation of the antithrombin Serpinc1 in Pon1−/− mice could increase thrombin activity, thereby increasing blood clotting, which might account for increased atherosclerotic lesions observed in these animals when fed with a high-fat diet [13].