Similarly, Zhu et al. [51] synthesized a liposome containing doxorubicin and hemoglobin to provide oxygen for overcoming the hypoxic conditions of the tumor microenvironment, resulting in increased efficacy of radiotherapy as well as ICD as measured by an increase in calreticulin translocation, HMGB1 expression, IFN-γ expression, and CD8+ T cell infiltration into the tumor in murine tumor models. This evidence concerns the gene HMGB1 and neoplasm.